Hydrochloric Acid → HCID 23329021, compound

HRID 261354Notes

Reaction equation

HRID 261354 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([CH:15]([CH3:25])[CH2:16][CH2:17][O:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1.C(O)C.Cl.[H][H]>C(OCC)(=O)C.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([CH:15]([CH3:25])[CH2:16][CH2:17][O:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:12]=[CH:13][CH:14]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 20499791HCID 20499791, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 23329021HCID 23329021, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 3-(3-benzyloxyphenyl)-1-phenoxybutane (11.2 g., 33.5 mM) in a mixture of ethyl acetate (110 ml.), ethanol (110 ml.) and concentrated hydrochloric acid (0.7 ml.) is hydrogenated for 2 hours under 60 p.s.i. hydrogen in the presence of 10% palladium-on-carbon (1.5 g.). Removal of the catalyst by filtration and concentration of the filtrate gives an oil. The oil is purified by chromatography on silica gel (100 g.) and eluting with benzene-ethyl acetate consisting of 0-10% ethyl acetate. The middle fractions are combined and concentrated to give the title product as an oil.

Workup

  1. customRemoval of the catalyst
  2. filtrationby filtration and concentration of the filtrate
  3. customgives an oil
  4. customThe oil is purified by chromatography on silica gel (100 g.)
  5. washeluting with benzene-ethyl acetate
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-e705d62a9d3f4412bcb0f04b269db530
Source dataset
uspto-grants-1979_08
Patent number
US04165323

Reaction notes

Loading…