Hydrochloric Acid → 3,7-Diaminoheptan-2-one dihydrochloride

HRID 261617Notes

Reaction equation

HRID 261617 reaction equation
C([NH:9][CH:10]([CH2:14][CH2:15][CH2:16][CH2:17][NH:18]C(=O)C1C=CC=CC=1)[C:11](=[O:13])[CH3:12])(=O)C1C=CC=CC=1.[ClH:27]>CC#N>[ClH:27].[ClH:27].[NH2:9][CH:10]([CH2:14][CH2:15][CH2:16][CH2:17][NH2:18])[C:11](=[O:13])[CH3:12]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 127698383,7-Dibenzamidoheptan-2-one

Product 1

HCID 127698393,7-Diaminoheptan-2-one dihydrochlorideYield 65%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Crude 3,7-dibenzamidoheptan-2-one (123 g, 0.35 mol) was hydrolysed by heating under reflux with concentrated HCl for 18 hours to give 3,7-diaminoheptan-2-one dihydrochloride (49 g, 65%), m.p. 160°-166° (MeCN). δ(60 MHzD2O) 4.3 (t,CH), 3.1 (t,NHC2), 2.35 (s,CH3), 1.7 (m(CH2)3).

Workup

  1. temperatureby heating

Sources & evidence

ORD record
ord-bea564ca40ea4bc396e0ce96b0366c93
Source dataset
uspto-grants-1979_08
Patent number
US04166184

Reaction notes

Loading…