反应详情

A two-liter reaction flask fitted with a magnetic stirrer, heating mantle, dropping funnel, thermometer, water-cooled condenser and Dean Stark trap was charged with 156.2 g (1.2 moles) of ethyl acetoacetate and 400 ml of xylene. The dropping funnel contained 161 g (1.0 mole) of 3-aminobenzotrifluoride and 320 ml xylene. The solution in the reaction pot was heated to 135° and the contents of the dropping funnel were added dropwise over a period of three hours. The low-boiling liquid which accumulated in the Dean Stark trap was periodically drained in order to maintain a reaction temperature of about 135°. After four hours, the reaction was judged to be completed and the reaction solution was cooled. There was added 650 ml of hexane. Cooling in an ice bath yielded a white crystalline precipitate. The product was collected on a vacuum filter and dried in an oven. There was obtained 136.6 g (55.7%) of 3'-trifluoromethylacetoacetanilide, m.p. 109°-10°. N.M.R. (CDCl3) ∂ 2.2 (CH3, keto), 3.5 (CH2), 7.2-7.9 (aromatic), 1.8 (CH3, enol).

1. customA two-liter reaction flask
2. customfitted with a magnetic stirrer
3. temperatureheating mantle
4. customThe solution in the reaction
5. temperaturepot was heated to 135°
6. additionthe contents of the dropping funnel were added dropwise over a period of three hours
7. temperatureto maintain a reaction temperature of about 135°
8. temperaturethe reaction solution was cooled
9. temperatureCooling in an ice bath
10. customyielded a white crystalline precipitate
11. customThe product was collected on a vacuum
12. filtrationfilter
13. customdried in an oven