HRID26176

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID712

Formaldehyde

CH2O

HCID1118

Sulfuric acid

H2O4S

HCID4875

Potassium iodide

HCID7859

Propargyl alcohol

C3H4O

HCID8021

Diethylamine

C4H11N

PRODUCTS

生成物

HCID82735

4-(Diethylamino)-2-butyn-1-ol

C8H15NO

收率 86%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID24462

Copper sulfate

CuO4S

溶剂HCID962

Water

H2O

CONDITIONS

反应条件

温度: 92 °C

PROCEDURE

实验过程

204 parts by weight of aqueous 55% strength propargyl alcohol, 250 parts by weight of 30% strength aqueous formaldehyde, 161 parts by weight of diethylamine, 1.4 parts by weight of copper sulfate, 2 parts by weight of potassium iodide, 50 parts by weight of water and 115 parts by weight of concentrated sulfuric acid are mixed and brought to pH 5. The mixture is heated for 5 hours at 92° C. and worked up as described. 242 parts by weight of 1-diethylaminobut-2-yn-4-ol are obtained, corresponding to a yield of 86%.