Hydrogen Peroxide → 3-Amino-5-pyrrolidino-thiazolo-(4,5-c)-isothiazole

HRID 262033Notes

Reaction equation

HRID 262033 reaction equation
[N:1]1([C:6]2[S:7][C:8]([C:12](=[S:14])[NH2:13])=[C:9]([NH2:11])[N:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.OO>C(O)(=O)C>[NH2:13][C:12]1[S:14][N:11]=[C:9]2[N:10]=[C:6]([N:1]3[CH2:2][CH2:3][CH2:4][CH2:5]3)[S:7][C:8]=12

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 125263542-Pyrrolidino-4-amino-5-thiocarbamoylthiazole

Product 1

HCID 125263703-Amino-5-pyrrolidino-thiazolo-(4,5-c)-isothiazole

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
22 °C

Procedure

5 parts of 2-pyrrolidino-4-amino-5-thiocarbamoylthiazole prepared as described in Example 3(a) and 3(b) are suspended in 50 parts of glacial acetic acid and 1 part of 50 percent strength by weight hydrogen peroxide is added at 20° C. Thereupon, the temperature rises to 30° C. After stirring for one hour at 22° C., the end product is precipitated by means of 100 parts of water, and is filtered off. 4.1 parts (82% of theory) of melting point 262°-264° C. are obtained.

Workup

  1. additionis added at 20° C
  2. customrises to 30° C
  3. customthe end product is precipitated by means of 100 parts of water
  4. filtrationis filtered off
  5. custom4.1 parts (82% of theory) of melting point 262°-264° C. are obtained

Sources & evidence

ORD record
ord-6877cc034124450ab2b0f2d7529bbcb2
Source dataset
uspto-grants-1979_05
Patent number
US04153607

Reaction notes

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