M-Cresol → alpha-(3-Methylphenoxy)acetophenone

HRID 262080Notes

Reaction equation

HRID 262080 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH3:8])[CH:5]=[CH:6][CH:7]=1.Br[CH2:10][C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12].C(=O)([O-])[O-].[K+].[K+]>C1C=CC=CC=1>[CH3:8][C:4]1[CH:3]=[C:2]([CH:7]=[CH:6][CH:5]=1)[O:1][CH2:10][C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12]

Participants

5

Reactant 3

HCID 342M-CresolHCID 6259Phenacyl bromideHCID 11430Potassium Carbonate

Product 1

HCID 14970243alpha-(3-Methylphenoxy)acetophenone

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

Equimolar amounts of 3-hydroxytoluene and α-bromoacetophenone are refluxed in benzene in the presence of potassium carbonate to provide α-(3-methylphenoxy)acetophenone.

Sources & evidence

ORD record
ord-1e804d32ef3c49c8bf98c31189e6da09
Source dataset
uspto-grants-1979_05
Patent number
US04153619

Reaction notes

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