HRID26210

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID2874204

Piperazine, 1-(3,4,5-trimethoxybenzoyl)-

C14H20N2O4

结构：CN1CCN(C(=O)c2c(Cl)n(-c3ccccc3)c3ccccc23)CC1

HCID85906066

未命名化合物

PRODUCTS

生成物

结构：COc1cc(C(=O)N2CCN(c3c(C(=O)N4CCN(C)CC4)c4ccccc4n3-c3ccccc3)CC2)cc(OC)c1OC

HCID86736460

未命名化合物

PROCEDURE

实验过程

This compound was prepared from 2-chloro-1-phenyl-indole 3-carboxylic acid 4-methyl-piperazide and 3,4,5-trimethoxy benzoic acid piperazide in boiling diglym according to Examples 7, 40, 42 and 45. The yield of amorphous product amounted to 77% of the theoretical yield. The hydrochloride melted at 253°-255° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-acfc8966c88142258d2c633c82f69485
来源数据集: uspto-grants-1979_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04148895
来源说明: uspto-grants-1979_04

反应 SMILES

[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:11]=2Cl)=[O:9])[CH2:4][CH2:3]1.[CH3:26][O:27][C:28]1[CH:29]=[C:30]([CH:39]=[C:40]([O:44][CH3:45])[C:41]=1[O:42][CH3:43])[C:31]([N:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1)=[O:32].Cl>>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:11]=2[N:36]2[CH2:37][CH2:38][N:33]([C:31](=[O:32])[C:30]3[CH:39]=[C:40]([O:44][CH3:45])[C:41]([O:42][CH3:43])=[C:28]([O:27][CH3:26])[CH:29]=3)[CH2:34][CH2:35]2)=[O:9])[CH2:4][CH2:3]1