反应详情

In 20 volume parts of ethanol is dissolved 2.16 parts of o-nitrobenzyl chloride, followed by the addition of 1.02 parts of N-methyl piperazine and 1.3 parts of potassium carbonate. The mixture is reacted under reflux for 1 hour. The reaction mixture is then filtered and the solvent is removed from the filtrate by distillation under reduced pressure. The residue is extracted with water-ether (1:1). The ethereal layer is taken and dried over anhydrous sodium sulfate and the solvent is then distilled off. This procedure gives N1 -methyl-N4 -(2-nitrobenzyl)piperazine as a brown colored oily substance.

1. customThe mixture is reacted
2. temperatureunder reflux for 1 hour
3. filtrationThe reaction mixture is then filtered
4. customthe solvent is removed from the filtrate by distillation under reduced pressure
5. extractionThe residue is extracted with water-ether (1:1)
6. dry with materialdried over anhydrous sodium sulfate
7. distillationthe solvent is then distilled off