Phthalic Anhydride → HCID 21318678, compound

HRID 262410Notes

Reaction equation

HRID 262410 reaction equation
[NH2:1][CH:2]([C:8]1[S:9][CH:10]=[CH:11][CH:12]=1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6].[C:13]1(=O)[O:18][C:16](=[O:17])[C:15]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:14]12.C1(C)C(C)=CC=CC=1.C(N(CC)CC)C>O>[C:13]1(=[O:18])[N:1]([CH:2]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)[CH2:3][CH2:4][C:5]([OH:7])=[O:6])[C:16](=[O:17])[C:15]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:14]12

Participants

6

Reactant 4

HCID 6811Phthalic AnhydrideHCID 7237O-XyleneHCID 8471TriethylamineHCID 21318673HCID 21318673, compound

Product 1

HCID 21318678HCID 21318678, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture containing one gram of 4-amino-4-(2-thienyl)butyric acid and 0.8 g. of phthalic anhydride in 25 ml. of xylene containing 0.55 g. of triethylamine is heated to reflux the water is removed by azeotroping. After 1.5 hours the mixture is cooled and stirred overnight at room temperature. It is then evaporated to dryness to afford the title compound as a glassy material.

Workup

  1. customis removed
  2. customby azeotroping
  3. temperatureAfter 1.5 hours the mixture is cooled
  4. customIt is then evaporated to dryness

Sources & evidence

ORD record
ord-6ab9d61969f2434986900ffaa4b20ce3
Source dataset
uspto-grants-1979_05
Patent number
US04154740

Reaction notes

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