Diazomethane → HCID 54140063, compound

HRID 262565Notes

Reaction equation

HRID 262565 reaction equation
[CH2:1]([S:3][C:4]([S:6][CH2:7][CH2:8][C:9]([N:11]1[CH2:18][CH2:17][CH2:16][C@H:12]1[C:13]([OH:15])=[O:14])=[O:10])=[S:5])[CH3:2].[N+](=[CH2:21])=[N-]>C(OCC)(=O)C.C(O)(=O)C>[CH3:21][O:14][C:13](=[O:15])[C@@H:12]1[CH2:16][CH2:17][CH2:18][N:11]1[C:9](=[O:10])[CH2:8][CH2:7][S:6][C:4]([S:3][CH2:1][CH3:2])=[S:5]

Participants

5

Reactant 2

HCID 9550DiazomethaneHCID 54024227HCID 54024227, compound

Product 1

HCID 54140063HCID 54140063, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 1-[3-[[(ethylthio)thiocarbonyl]thio]propanoyl]-L-proline in ethyl acetate is treated with an ethereal solution of diazomethane until persistent yellow color. After discharging the yellow color with a few drops of acetic acid, the solvents are removed in vacuo to yield 1-[3-[[(ethylthio)thiocarbonyl]thio]propanoyl]-L-proline methyl ester.

Workup

  1. customthe solvents are removed in vacuo

Sources & evidence

ORD record
ord-21a3633d16ab4f6993fd76f4d3a0f7d8
Source dataset
uspto-grants-1979_05
Patent number
US04154840

Reaction notes

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