反应详情

1-[3-(benzylthio)-2-methylpropanoyl]-L-proline tert.butyl ester (7.8 g.) is dissolved in a mixture of anisole (55 ml.) and trifluoroacetic acid (110 ml.). After one hour storage at room temperature, the solvent is removed in vacuo and the residue is dissolved in ether, washed several times with saturated sodium chloride, dried over magnesium sulfate and evaporated to dryness in vacuo to yield 1-[3-(benzylthio)-2-methylpropanoyl]-L-proline. Rf 0.5 (Silica gel, Benzene/acetic acid 3:1) Rf 0.5. (Silica gel, Methyl-ethylketone/acetic acid/pyridine/water 14:1:2:1).

1. customthe solvent is removed in vacuo
2. dissolutionthe residue is dissolved in ether
3. washwashed several times with saturated sodium chloride
4. dry with materialdried over magnesium sulfate
5. customevaporated to dryness in vacuo