Phosphoric Acid → HCID 54301983, compound

HRID 262732Notes

Reaction equation

HRID 262732 reaction equation
C([O:4][C:5]1[CH:6]=[CH:7][C:8]2[CH2:9][C@H:10]3[N:21]([C:22]([O:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)=[O:23])[CH2:20][CH2:19][C@@:16]4([C:17]=2[CH:18]=1)[C@H:11]3[CH2:12][CH2:13][O:14][CH2:15]4)(=O)C.[OH-].[K+].P(=O)(O)(O)O>CC(O)C.O>[C:22]([N:21]1[CH2:20][CH2:19][C@@:16]23[C:17]4[CH:18]=[C:5]([OH:4])[CH:6]=[CH:7][C:8]=4[CH2:9][C@@H:10]1[C@@H:11]2[CH2:12][CH2:13][O:14][CH2:15]3)([O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:23]

Participants

6

Reactant 3

HCID 1004Phosphoric AcidHCID 14797Potassium HydroxideHCID 53916716HCID 53916716, compound

Product 1

HCID 54301983HCID 54301983, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3776IsopropanolSolvent

Conditions

Temperature
10 °C

Procedure

A cooled solution of XXVII from Step (b) above (0.01 m) in 25 ml 2-propanol (~10° C.) is treated with a solution of potassium hydroxide (3 g) in 25 ml water and is stirred under nitrogen at 10° C. for 2 hours. The reaction mixture is acidified with phosphoric acid and the 2-propanol removed at reduced pressure. The aqueous mixture is extracted with methylene chloride. The extracts are dried (MgSO4) and concentrated to produce the title compound.

Workup

  1. customthe 2-propanol removed at reduced pressure
  2. extractionThe aqueous mixture is extracted with methylene chloride
  3. dry with materialThe extracts are dried (MgSO4)
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-c3d7c2d008b74e8a83c38079b29d62ed
Source dataset
uspto-grants-1979_05
Patent number
US04154932

Reaction notes

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