Trifluoroacetic acid → HCID 44279963, compound

HRID 262918Notes

Reaction equation

HRID 262918 reaction equation
[CH2:1]([NH:17][C:18]1[CH:38]=[CH:37][C:21]([C:22]([CH:24](C(OCC)=O)[C:25]([O:27][C:28](C)(C)[CH3:29])=[O:26])=[O:23])=[CH:20][CH:19]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].FC(F)(F)C(O)=O.[OH-].[K+]>>[CH2:1]([NH:17][C:18]1[CH:19]=[CH:20][C:21]([C:22]([CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])=[O:23])=[CH:37][CH:38]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 14797Potassium HydroxideHCID 21318818HCID 21318818, compound

Product 1

HCID 44279963HCID 44279963, compound

Procedure

A solution of 3.0 g. of t-butyl ethyl p-(hexadecylamino)benzoylmalonate in 10 ml. of trifluoroacetic acid is warmed with stirring for 3 hours. The solution is poured onto ice and neutralized with potassium hydroxide. The resulting precipitate is washed with water and dried. Recrystallization from chloroform gives the desired product.

Workup

  1. washThe resulting precipitate is washed with water
  2. customdried
  3. customRecrystallization from chloroform

Sources & evidence

ORD record
ord-0fbc55391f1a4f71a7ed65766bd2a5d7
Source dataset
uspto-grants-1979_05
Patent number
US04154756

Reaction notes

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