HCID 21317706, compound → HCID 21317682, compound

HRID 262980Notes

Reaction equation

HRID 262980 reaction equation
[C:1]([NH:4][NH:5][C:6]1[CH2:7][N:8]=[C:9]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=2)[C:10]2[CH:15]=[C:14]([Cl:16])[S:13][C:11]=2[N:12]=1)(=O)[CH3:2]>C1(C)C(C)=CC=CC=1>[Cl:16][C:14]1[S:13][C:11]2[N:12]3[C:1]([CH3:2])=[N:4][N:5]=[C:6]3[CH2:7][N:8]=[C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[C:10]=2[CH:15]=1

Participants

3

Reactant 1

HCID 21317706HCID 21317706, compound

Product 1

HCID 21317682HCID 21317682, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

2.2 g of 2-(2-acetylhydrazino)-7-chloro-5-(2-pyridyl)-3H-thieno[2,3-e]-1,4-diazepine are refluxed for 2 hours in 120 ml of absolute xylene. The solution is then cooled and the precipitated impurities are filtered off. The solvent is evaporated under reduced pressure and there is obtained 2-chloro-9-methyl-4-(2-pyridyl)-6H-thieno[3,2-f]-s-triazolo[4,3-a][1,4]diazepine in the form of a crystalline product which, after recrystallization from ethyl acetate, melts at 174°-176° C.

Workup

  1. temperatureThe solution is then cooled
  2. filtrationthe precipitated impurities are filtered off
  3. customThe solvent is evaporated under reduced pressure

Sources & evidence

ORD record
ord-1571cb39e48b4ba8837c9d36da312d2c
Source dataset
uspto-grants-1979_05
Patent number
US04155913

Reaction notes

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