Dimethylamine → HCID 70607993, compound

HRID 263226Notes

Reaction equation

HRID 263226 reaction equation
[O:1]1[C:5](=[O:6])[CH2:4][C@@H:3]2[CH2:7][C:8]3[C:13]([CH2:14][C@@H:2]12)=[CH:12][CH:11]=[CH:10][CH:9]=3.[CH3:15][NH:16][CH3:17]>C1COCC1>[CH3:15][N:16]([CH3:17])[C:5](=[O:6])[CH2:4][C@@H:3]1[CH2:7][C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:14][C@H:2]1[OH:1]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 22808058HCID 22808058, compound

Product 1

HCID 70607993HCID 70607993, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 18.8 (0.10 mol) of trans-3a, 4,9,9a-tetrahydronaphtho[2,3-b]furan-2(3H)-one, 35 ml of anhydrous dimethylamine, and 35 ml of dry THF is heated in a small Parr bomb at 100° for 3 days. The cooled reaction mixture is then taken to dryness in vacuo, and the residue triturated with ether to give 22.5 g (97%) of crystalline solid after drying in vacuo.

Workup

  1. temperatureis heated in a small Parr bomb at 100° for 3 days
  2. customThe cooled reaction mixture
  3. customthe residue triturated with ether

Sources & evidence

ORD record
ord-85f0a30f0f794270935a0322868da900
Source dataset
uspto-grants-1979_05
Patent number
US04156723

Reaction notes

Loading…