反应详情

3.9 g (20 mmole) of 7-hydroxy-2-methylchromen-4-one, 4.4 ml (40 mmole) of 1-bromo-3-chloropropane and 6.1 g (40 mmole) of anhydrous potassium carbonate in 100 ml of acetone were mixed and refluxed under heating for 16 hours. The mixture was allowed to cool and the insoluble solid was separated by filtration. The filtrate was evaporated to dryness, and the residue obtained was suspended in ethyl ether, filtered, washed with ether and dried at vaccum to yield 4.76 g (85%) of the product, melting point 113°-115° C.

1. temperaturerefluxed
2. temperatureunder heating for 16 hours
3. temperatureto cool
4. customthe insoluble solid was separated by filtration
5. customThe filtrate was evaporated to dryness
6. customthe residue obtained
7. filtrationfiltered
8. washwashed with ether
9. customdried at vaccum