Sodium Iodide → HCID 10448329, compound

HRID 263491Notes

Reaction equation

HRID 263491 reaction equation
S(O[CH2:12][CH:13]([CH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)(C1C=CC(C)=CC=1)(=O)=O.[I-:26].[Na+]>CC(C)=O>[CH:20]1([CH:13]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:12][I:26])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]1

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 9975688HCID 9975688, compound

Product 1

HCID 10448329HCID 10448329, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a 250 mL round-bottomed flask equipped with condenser and N2 inlet were added 13.9 g (39.4 mmol) 2-(cyclohexyl)-2-phenylethanol tosylate, 80 mL acetone and 6.49 g (43.3 mmol) sodium iodide. The reaction was refluxed 36 hr, cooled, and evaporated. The residue was taken up in ethyl acetate, washed with water and aqueous sodium bisulfite solution, dried over sodium sulfate, and evaporated to an oil, 12.11 g (98%), which was used directly in the next step.

Workup

  1. customTo a 250 mL round-bottomed flask equipped with condenser and N2 inlet
  2. temperatureThe reaction was refluxed 36 hr
  3. temperaturecooled
  4. customevaporated
  5. washwashed with water and aqueous sodium bisulfite solution
  6. dry with materialdried over sodium sulfate
  7. customevaporated to an oil, 12.11 g (98%), which

Sources & evidence

ORD record
ord-48a9268957614d76ab6a192301a69999
Source dataset
uspto-grants-1997_07
Patent number
US05643904

Reaction notes

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