Lithium Hydroxide → HCID 22874283, compound

HRID 263759Notes

Reaction equation

HRID 263759 reaction equation
[C:1]([NH:8][C@H:9]([C@H:18]1[O:22][C:21](=[O:23])[C@H:20]([CH2:24][C:25]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=2)[CH2:19]1)[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[OH-:35].[Li+]>C(COC)OC.O>[C:1]([NH:8][C@@H:9]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)[C@@H:18]([OH:22])[CH2:19][C@@H:20]([CH2:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]([F:32])([F:33])[F:34])=[CH:27][CH:26]=1)[C:21]([OH:23])=[O:35])([O:3][C:4]([CH3:5])([CH3:7])[CH3:6])=[O:2]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 70088514HCID 70088514, compound

Product 1

HCID 22874283HCID 22874283, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 80711,2-DimethoxyethaneSolvent

Procedure

Analogously to Example 1 i), 1.05 g of 5(S)-[1(S)-(Boc-amino)-2-(p-fluorophenyl)ethyl]-3(R)-(p-trifluoromethylphenylmethyl)-dihydrofuran-2-(3H)-one in 35.5 ml of dimethoxyethane and 17.9 ml of water are hydrolysed with 8.7 ml of 1 M lithium hydroxide solution to form the title compound which is used further directly.

Sources & evidence

ORD record
ord-5e1e06fb018d4844a8a34e56bb08e06e
Source dataset
uspto-grants-1997_07
Patent number
US05643878

Reaction notes

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