反应详情

温度

-10 °C

1.3 g (10 mmol) of 4-fluoro-2-methylaniline were introduced into 10 ml of concentrated sulfuric acid and cooled to -10° C. A cold solution of 0.4 ml (10 mmol) of fuming nitric acid in 2 ml of concentrated sulfuric acid was added slowly dropwise. The resulting mixture was stirred for 3 hours at 0° C. and subsequently poured into ice. The precipitated product was filtered with suction and washed. 0.85 g (50% of the theoretical yield) of product was obtained. The yellow crystalline product had a melting point of 178° C.

1. additionsubsequently poured into ice
2. filtrationThe precipitated product was filtered with suction
3. washwashed
4. custom0.85 g (50% of the theoretical yield) of product
5. customwas obtained