Diisopropylaniline → (+/-)-5-(dodecylthio)-alpha-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-2-acetamide

HRID 264084Notes

Reaction equation

HRID 264084 reaction equation
[CH2:1]([S:13][C:14]1[N:15]=[N:16][N:17]([CH:19]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:20]([OH:22])=O)[N:18]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].C(C1N=NN(CC(O)=O)N=1)CCCCCCCCC.[CH3:48][O:49][C:50]1[CH:56]=[C:55]([O:57][CH3:58])[CH:54]=[C:53]([O:59][CH3:60])[C:51]=1[NH2:52].C(C1C=CC=C(C(C)C)C=1N)(C)C>>[CH2:1]([S:13][C:14]1[N:15]=[N:16][N:17]([CH:19]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:20]([NH:52][C:51]2[C:53]([O:59][CH3:60])=[CH:54][C:55]([O:57][CH3:58])=[CH:56][C:50]=2[O:49][CH3:48])=[O:22])[N:18]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

Participants

5

Reactant 4

HCID 32484DiisopropylanilineHCID 842712,4,6-TrimethoxyanilineHCID 21469499(+/-)-5-(dodecylthio)-alpha-phenyl-2H-tetrazole-2-acetic acidHCID 214695295-decyl-2H-tetrazole-2-acetic acid

Product 1

HCID 21469548(+/-)-5-(dodecylthio)-alpha-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-2-acetamide

Procedure

When in the general procedure of Example 88 an appropriate amount of (±)-5-(dodecylthio)-α-phenyl-2H-tetrazole-2-acetic acid was substituted for 5-decyl-2H-tetrazole-2-acetic acid and 2,4,6-trimethoxyaniline was substituted for 2,6-diisopropylaniline, the title compound was obtained, mp 141°-143° C.

Sources & evidence

ORD record
ord-4b485d04e504456cb1d150310c3c314f
Source dataset
uspto-grants-1997_07
Patent number
US05646170

Reaction notes

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