反应详情

A solution of 8 g of 6-methoxycarbonyl-1-indanone, 8 ml of 3-buten-2-ol and 100 mg of p-toluenesulfonic acid in 80 ml of 2,2-dimethoxy-propane was boiled under reflux for 28 hours on a water separator filled with molecular sieve (0.4 nm, 2 mm pearl shaped). The reaction mixture was subsequently concentrated in a vacuum and purified by column chromatography on silica gel (hexane/ethyl acetate 3:1). In addition to 1.3 g of educt, there were obtained 8.5 g (83%) of (RS)-2-(2-buten-1-yl)-6-methoxycarbonyl-1-indanone as a yellow oil.

1. additionseparator filled with molecular sieve (0.4 nm, 2 mm pearl shaped)
2. concentrationThe reaction mixture was subsequently concentrated in a vacuum
3. custompurified by column chromatography on silica gel (hexane/ethyl acetate 3:1)
4. additionIn addition to 1.3 g of educt