反应详情

To a solution of 5.4 g of 2-(4-isobutylphenyl)propionic acid chloride and 3.7 g of m-fluorobenzyl alcohol in 30 ml of tetrahydrofuran was added 3.7 g of triethylamine, dropwise under cooling, and the mixture was reacted at room temperature for 1.5 hours. After the reaction was complete, the crystals procuced were removed by filtration. The filtrate was freed of solvent by distillation to leave a residue, to which was added water. The resulting mixture was extracted with ether. The ether extract was dehydrated and freed of ether by distillation. The oily residue thus obtained was distilled in vacuo to yield 5.9 g of 2-(4-isobutylphenyl)propionic acid-m-fluorobenzyl ester as a colorless oil, boiling at 143°-144° C./0.2 mmHg. Mass spectrum: parent ion 314 m/e.

1. temperaturedropwise under cooling
2. customthe mixture was reacted at room temperature for 1.5 hours
3. customthe crystals procuced were removed by filtration
4. distillationThe filtrate was freed of solvent by distillation
5. customto leave a residue
6. extractionThe resulting mixture was extracted with ether
7. extractionThe ether extract
8. distillationfreed of ether by distillation
9. customThe oily residue thus obtained
10. distillationwas distilled in vacuo