反应详情

A solution of 21.5 g of 4-methoxy-1-indanone, 27.4 ml of 3-buten-2-ol and 210 mg of p-toluenesulfonic acid in 27.4 ml of 2,2-dimethoxypropane and 210 ml of anhydrous toluene was boiled under reflux for 16 hours. The reaction mixture was subsequently concentrated in a vacuum and purified by column chromatography on silica gel (hexane/ethyl acetate 9:1). 6.42 g (23%) of (RS)-2-(2-buten-1-yl)-4-methoxy-1-indanone were obtained as a yellow oil.

1. temperatureunder reflux for 16 hours
2. concentrationThe reaction mixture was subsequently concentrated in a vacuum
3. custompurified by column chromatography on silica gel (hexane/ethyl acetate 9:1)