反应详情

9.6 g (0.24 mol) of 60% sodium hydride and 150 ml of N,N-dimethylformamide were placed in a container equipped with a stirrer, a reflux condenser and a nitrogen-introducing tube, and the solution was then stirred under the feed of nitrogen. Afterward, 35 g (0.25 mol) of 3,5-dimethyl-1,6-heptadiene-4-ol was added dropwise thereto at 20°-30° C. over 1 hour, and the solution was then stirred at the same temperature for 3 hours to prepare a sodium alcoholate solution. Next, 34.6 g (0.2 mol) of 3-nitrophthalonitrile and 150 ml of N,N-dimethylformamide were placed in a container equipped with a stirrer, and the above-mentioned sodium alcoholate solution was added dropwise thereto at 0° C. or less over 5 hours. After completion of the addition, the temperature of the solution was raised up to a level of 20°-30° C., and the solution was then stirred for 3 hours to bring reaction to an end. The thus obtained reaction solution was poured into 3 l of water and then stirred for 30 minutes, and 500 ml of toluene were added. After stirring for 30 minutes, the resulting toluene layer was separated. After toluene was distilled off under reduced pressure, recrystallization was carried out from 600 ml of n-hexane to obtain 44.7 g of 3-(3,5-dimethyl-1,6-heptadiene-4-oxy)phthalonitrile (yield=84.0%).

1. customequipped with a stirrer, a reflux condenser
2. additiona nitrogen-introducing tube
3. stirringthe solution was then stirred at the same temperature for 3 hours
4. customequipped with a stirrer
5. waitat 0° C. or less over 5 hours
6. additionAfter completion of the addition
7. temperaturethe temperature of the solution was raised up to a level of 20°-30° C.
8. stirringthe solution was then stirred for 3 hours
9. customreaction to an end
10. customThe thus obtained reaction solution
11. stirringstirred for 30 minutes
12. stirringAfter stirring for 30 minutes
13. customthe resulting toluene layer was separated
14. distillationAfter toluene was distilled off under reduced pressure, recrystallization