反应详情

To a solution of 6.8 g of 2-phenylimidazole in 200 mL 3N hydrochloric acid was added 5% Rhodium on Carbon, Degussa type G10 NB/W. The mixture was hydrogenated at 100 psi for 24 hours then filtered through celite. The solution was neutralized with 25% sodium hydroxide and extracted with 2×100 mL ethyl acetate. The combined extract was washed with 200 mL of brine and dried over anhydrous sodium sulfate. Evaporation of the solvent gave 2-cyclohexylimidazole as a fluffy, white solid which was used in the next step without further purification or characterization.

1. filtrationthen filtered through celite
2. extractionextracted with 2×100 mL ethyl acetate
3. extractionThe combined extract
4. washwas washed with 200 mL of brine
5. dry with materialdried over anhydrous sodium sulfate
6. customEvaporation of the solvent