Hydrochloric Acid → 2,2-bis(fluoromethyl)-6-trifluoromethyl-2H-1-benzopyran-4-carboxylic acid

HRID 264854Notes

Reaction equation

HRID 264854 reaction equation
C([O:3][C:4]([C:6]1[C:11]2[CH:12]=[C:13]([C:16]([F:19])([F:18])[F:17])[CH:14]=[CH:15][C:10]=2[O:9][C:8]([CH2:22][F:23])([CH2:20][F:21])[CH:7]=1)=[O:5])C.[OH-].[K+].Cl>C(O)C>[F:23][CH2:22][C:8]1([CH2:20][F:21])[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[C:11]2[CH:12]=[C:13]([C:16]([F:19])([F:17])[F:18])[CH:14]=[CH:15][C:10]=2[O:9]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 19037095ethyl 2,2-bisfluoromethyl-6-trifluoromethyl-2H-1-benzopyran-4-carboxylate

Product 1

HCID 98796402,2-bis(fluoromethyl)-6-trifluoromethyl-2H-1-benzopyran-4-carboxylic acidYield 92%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 0.51 g of 2,2-bis(fluoromethyl)-6-trifluoromethyl-2H-1-benzopyran-4-carboxylic acid ethyl ester, 0.13 g of potassium hydroxide and 10 ml of ethyl alcohol was stirred at room temperature for 2 hours. To the reaction mixture was added ice water and hydrochloric acid and crystals separated out were filtered to obtain 0.43 g of 2,2-bis(fluoromethyl)-6-trifluoromethyl-2H-1-benzopyran-4-carboxylic acid.

Workup

  1. customseparated out
  2. filtrationwere filtered

Sources & evidence

ORD record
ord-a51aa7638b0e453fbbcd1c8ef96b1368
Source dataset
uspto-grants-1997_07
Patent number
US05646308

Reaction notes

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