反应详情

A mixture of 2,4,5-triphenyl-1-(7-bromoheptyl)-imidazole (0.95 g) and triethyl phosphite (1.66 g) in xylene (5 ml) was heated at reflux temperature for 20 hours. The mixture was evaporated to an oil and chromatographed on silica gel (ethyl acetate/ethanol) to give diethyl 7-(2,4,5-triphenylimidazol-1-yl)heptane-phosphonate (0.37 g, 35%) as a light brown oil.

1. temperaturewas heated
2. temperatureat reflux temperature for 20 hours
3. customThe mixture was evaporated to an oil
4. customchromatographed on silica gel (ethyl acetate/ethanol)