反应详情

To a solution of 4-pyridinecarboxyaldehyde (1.07 g, 10 mmol) and allylamine (0.61 g, 10 mmol) in ether (30 ml) was added anhydrous sodium carbonate (2.76 g). The solution was stirred at r.t. overnight, then sodium carbonate was filtered off. To the reaction mixture, diphenylphosphite (2.34 g, 10 mmol) and triethylamine (1.01 g, 10 mmol) were added with cooling over an ice-water bath. It was stirred at r.t. overnight. After removal of the solvent an oily residue was obtained which was chromatographed (1:1 Petroleum ether/ethyl acetate) to give 2.85 g (65%) as an oil.

1. filtrationsodium carbonate was filtered off
2. temperaturewith cooling over an ice-water bath
3. stirringIt was stirred at r.t. overnight
4. customAfter removal of the solvent an oily residue
5. customwas obtained which
6. customwas chromatographed (1:1 Petroleum ether/ethyl acetate)
7. customto give 2.85 g (65%) as an oil