Triethylsilane → HCID 19034148, compound

HRID 265865Notes

Reaction equation

HRID 265865 reaction equation
C([O:5][C:6](=[O:34])[CH2:7][CH:8]([C:30](=[O:33])[CH2:31][CH3:32])[NH:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2(O)[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]2)=[CH:12][CH:11]=1)(C)(C)C.[SiH](CC)(CC)CC>C(Cl)Cl>[NH:19]1[CH2:20][CH2:21][CH:16]([C:13]2[CH:14]=[CH:15][C:10]([NH:9][CH:8]([C:30](=[O:33])[CH2:31][CH3:32])[CH2:7][C:6]([OH:34])=[O:5])=[CH:11][CH:12]=2)[CH2:17][CH2:18]1

Participants

4

Reactant 2

HCID 12052TriethylsilaneHCID 67721239HCID 67721239, compound

Product 1

HCID 19034148HCID 19034148, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 10-6 (0.225 g, 0.47 mmoles) in CH2Cl2 (5 ml) was treated with Et3SiH (0.33 g, 4.2 mmoles) at ambient temperature and the resulting solution was stirred for 18 hours. The solvent was removed and the residue was purified by flash chromatgraphy on silica gel eluting with EtOH(10)/H2O(1)/NH4OH(1) to give two components: 10-8 had Rf 0.25 under these conditions:

Workup

  1. customThe solvent was removed
  2. customthe residue was purified by flash chromatgraphy on silica gel eluting with EtOH(10)/H2O(1)/NH4OH(1)
  3. customto give two components

Sources & evidence

ORD record
ord-971910cbdcf84c169fcde17cdb566dce
Source dataset
uspto-grants-1997_07
Patent number
US05648368

Reaction notes

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