Hydrochloric Acid → HCID 86751092, compound

HRID 265899Notes

Reaction equation

HRID 265899 reaction equation
C([O:5][C:6](=[O:37])[C@@H:7]([NH:27][S:28]([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)(=[O:30])=[O:29])[CH2:8][NH:9][C:10](=[O:26])[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][CH2:20][N:21]2[CH:25]=[CH:24][N:23]=[CH:22]2)=[CH:13][CH:12]=1)(C)(C)C.Cl>CCOC(C)=O>[N:21]1([CH2:20][CH2:19][CH2:18][O:17][C:14]2[CH:13]=[CH:12][C:11]([C:10]([NH:9][CH2:8][C@H:7]([NH:27][S:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)(=[O:30])=[O:29])[C:6]([OH:37])=[O:5])=[O:26])=[CH:16][CH:15]=2)[CH:25]=[CH:24][N:23]=[CH:22]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86751093HCID 86751093, compound

Product 1

HCID 86751092HCID 86751092, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
0 °C

Procedure

A solution of 27-4 (1.2 g, 2.27 mmol) in EtOAc (15 mL) was cooled to -78° C. and saturated with HCl gas. This solution was warmed to 0° C. for 1.5 hours, degassed with argon and concentrated to give a colorless oil, which was chromatographed (10:0.5:0.5 EtOH/H2O/NH4OH) to give 27-5 as a white solid.

Workup

  1. customdegassed with argon
  2. concentrationconcentrated
  3. customto give a colorless oil, which
  4. customwas chromatographed (10:0.5:0.5 EtOH/H2O/NH4OH)

Sources & evidence

ORD record
ord-e645d4cebfaa4a5ba14a2f2401cbb149
Source dataset
uspto-grants-1997_07
Patent number
US05648368

Reaction notes

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