Hydrochloric Acid → Ammonium Hydroxide

HRID 265904Notes

Reaction equation

HRID 265904 reaction equation
C([O:5][C:6](=[O:38])[C@@H:7]([NH:28][S:29]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)(=[O:31])=[O:30])[CH2:8][NH:9][C:10](=[O:27])[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH:19]=[CH:20][CH2:21][N:22]2[CH2:26][CH2:25][CH2:24][CH2:23]2)=[CH:13][CH:12]=1)(C)(C)C.Cl.CCO>O>[NH4+:9].[OH-:5].[N:22]1([CH2:21][CH:20]=[CH:19][CH2:18][O:17][C:14]2[CH:15]=[CH:16][C:11]([C:10]([NH:9][CH2:8][C@H:7]([NH:28][S:29]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)(=[O:31])=[O:30])[C:6]([OH:38])=[O:5])=[O:27])=[CH:12][CH:13]=2)[CH2:26][CH2:25][CH2:24][CH2:23]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 86751095HCID 86751095, compound

Product 2

HCID 14923Ammonium HydroxideHCID 86751094HCID 86751094, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The compound 30-5 (0.22 g, 0.43 mmol) was treated with 6N HCl (20 mL) for 24 h at room temperature and 1.5 h at 60° C. Concentration of the solution and chromatography of the residue (SiO2, 9:1:1 EtOH, H2O, NH4OH) gave 30-6 as a white solid. Rf (9:1:1 EtOH/H2O/NH4OH) 0.69.

Sources & evidence

ORD record
ord-d69f6d2aab55493b847f5fd9554f79f3
Source dataset
uspto-grants-1997_07
Patent number
US05648368

Reaction notes

Loading…