Hydrochloric Acid → HCID 22874920, compound

HRID 265910Notes

Reaction equation

HRID 265910 reaction equation
[C:1]1([S:7]([NH:10][C@@H:11]([CH2:19][CH2:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([O:28][CH2:29][CH2:30][CH2:31][C:32]3[N:33]=[CH:34][N:35]([CH3:37])[CH:36]=3)=[CH:24][CH:23]=2)[C:12]([O:14]C(C)(C)C)=[O:13])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl>CCOC(C)=O>[C:1]1([S:7]([NH:10][C@@H:11]([CH2:19][CH2:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([O:28][CH2:29][CH2:30][CH2:31][C:32]3[N:33]=[CH:34][N:35]([CH3:37])[CH:36]=3)=[CH:24][CH:23]=2)[C:12]([OH:14])=[O:13])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22874943HCID 22874943, compound

Product 1

HCID 22874920HCID 22874920, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
0 °C

Procedure

A solution of 35-9 (0.055 g, 0.127 mmol) in EtOAc (1 mL) was cooled to -78° C., and saturated with HCl gas. The reaction was warmed to 0° C. for 1/2 hr, then concentrated and the residue chromatographed (20:1:1 EtOH/NH4OH/H2O) to give 35-10 as a white solid.

Workup

  1. concentrationconcentrated
  2. customthe residue chromatographed (20:1:1 EtOH/NH4OH/H2O)

Sources & evidence

ORD record
ord-f13616bb926a445fb43bc00081905cc0
Source dataset
uspto-grants-1997_07
Patent number
US05648368

Reaction notes

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