Diethylamine → HCID 70281469, compound

HRID 266142Notes

Reaction equation

[Cl:1][CH2:2][C:3]1[C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:11]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][CH:27]([CH3:29])[CH3:28])[CH:19]=2)[C:10]2[C:5](=[CH:6][C:7]([O:32][CH3:33])=[C:8]([O:30][CH3:31])[CH:9]=2)[N:4]=1.[CH2:34]([NH:36][CH2:37][CH3:38])[CH3:35]>>[ClH:1].[ClH:1].[CH2:34]([N:36]([CH2:2][C:3]1[C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:11]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][CH:27]([CH3:29])[CH3:28])[CH:19]=2)[C:10]2[C:5](=[CH:6][C:7]([O:32][CH3:33])=[C:8]([O:30][CH3:31])[CH:9]=2)[N:4]=1)[CH2:37][CH3:38])[CH3:35]

Participants

Reactant 2

HCID 8021Diethylamine

HCID 10624326HCID 10624326, compound

Product 1

HCID 70281469HCID 70281469, compound

Procedure

According to the same manner as that described in Example 14, ethyl 2-chloromethyl-4-(3-isopropoxy-4-methoxyphenyl)-6,7-dimethoxyquinoline-3-carboxylate was reacted with diethylamine to give ethyl 2-(N,N-diethylaminomethyl)-4-(3-isopropoxy-4-methoxyphenyl)-6,7-dimethoxyquinoline-3-carboxylate dihydrochloride. This compound was recrystallized from ethyl acetate - ether. Yellow powder, mp. 122°-124° C.

Sources & evidence

ORD record: ord-f2489688aff94ad5a84aa810f05297bb
Source dataset: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05650410

Reaction notes

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