N-methyl-2-pyrrolidone → HCID 53723146, compound

HRID 266216Notes

Reaction equation

HRID 266216 reaction equation
F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[CH3:10][O:11][C:12]([CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]2S(=O)(=O)[NH:25][CH2:24][CH2:23]2)=[CH:18][CH:17]=1)=[O:13].[H-].[Na+].CN1CCC[C:33]1=[O:37]>[Cu]>[C:6]([C:5]1[CH:8]=[CH:9][C:2]([N:25]2[CH2:24][CH2:23][N:22]([CH:19]3[CH2:20][CH2:21][CH:16]([CH2:15][CH2:14][C:12]([O:11][CH3:10])=[O:13])[CH2:17][CH2:18]3)[C:33]2=[O:37])=[CH:3][CH:4]=1)#[N:7]

Participants

5

Reactant 3

HCID 13387N-methyl-2-pyrrolidoneHCID 24758Sodium hydrideHCID 86751107HCID 86751107, compound

Product 1

HCID 53723146HCID 53723146, compound

Reagents, catalysts & solvents 1

HCID 23978CopperCatalyst

Procedure

2-64=cyano-phenyl)-5-[4-(2-methoxycarbonyl-ethyl)-phenyl]-3,4-dihydro-2H,5H-1,2,5-thiadiazole-1,1-dioxide 4-Fluoro-benzonitrile and sodium hydride in N-methyl-pyrrolidone were used without copper salts.

Sources & evidence

ORD record
ord-e6eccbfeb4354147acccc1596ced1ed8
Source dataset
uspto-grants-1997_07
Patent number
US05650424

Reaction notes

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