反应详情

To α-hydroxyimino-2-phenoxyphenylacetonitrile (a mixture of E- and Z-isomers) (1.19 9, 0.005 mole) were added dried dimethylformamide (10 ml) and potassium carbonate 0.90 g, 0.0065 mole), and dimethylsulfate (0.76 g, 0.006 mole) was added dropwise to the mixture under ice cooling, followed by stirring at room temperature for 1.5 hours. After completion of the reaction, ether (150 ml) was added, followed by washing twice with water (100 ml). The ether layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure, and then the resulting residue was purified by silica gel chromatography (ethyl acetate/n-hexane) to obtain α-methoxyimino-2-phenoxyphenylacetonitrile (1.13 g, yield: 89.6%) as a colorless oil.

1. additionwas added dropwise to the mixture under ice cooling
2. additionwas added
3. washby washing twice with water (100 ml)
4. dry with materialThe ether layer was dried over anhydrous magnesium sulfate
5. concentrationconcentrated under reduced pressure
6. customthe resulting residue was purified by silica gel chromatography (ethyl acetate/n-hexane)