Water → HCID 86747131, compound

HRID 266466Notes

Reaction equation

HRID 266466 reaction equation
C1(C2N(S[CH2:13][N:14]3[C:24](=[O:25])[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][C:22]=4[CH2:26][CH3:27])[S:15]3(=[O:17])=[O:16])N=NN=2)C=CC=CC=1.[Na].[C:29]1([N:35]2[C:39]([SH:40])=[N:38][N:37]=[N:36]2)[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1.O>CN(C)C=O>[C:29]1([N:35]2[C:39](=[S:40])[N:38]([CH2:13][N:14]3[C:24](=[O:25])[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][C:22]=4[CH2:26][CH3:27])[S:15]3(=[O:16])=[O:17])[N:37]=[N:36]2)[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

Participants

5

Reactant 3

HCID 962WaterHCID 70051983HCID 70051983, compoundHCID 178527989HCID 178527989, compound

Product 1

HCID 86747131HCID 86747131, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 2-(5-phenyl-1-tetrazolyl)thiomethyl-4-ethylsaccharin (Example 30AE, 0.020 g) and 1-phenyltetrazol-5-thiol sodium salt (0.0026 g) in dimethylformamide (1 mL) was heated at 100° C. for three days, then poured into water. Recrystallization of the resulting solid from ethanol-water afforded 2-(4-phenyl-5-thioxo-1-tetrazolyl)methyl-4-ethylsaccharin, 0.012 g, 60% yield, mp 127°-129° C.

Workup

  1. customwas heated at 100° C. for three days
  2. customRecrystallization of the resulting solid from ethanol-water

Sources & evidence

ORD record
ord-682a082d5d3545fb84747d7ab80803b1
Source dataset
uspto-grants-1997_07
Patent number
US05650422

Reaction notes

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