反应详情

A mixture of ethyl-2-(diethoxyphosphinyl)propionate (15 g., 0.063 moles) in 6 N hydrochloric acid (150 ml.) is heated to reflux for 2.5 hours. After this time, the reaction vessel is fitted with a Dean-Stark trap and heated at reflux an additional thirty minutes. The reaction mixture is concentrated in vacuo to yield 2-phosphonopropionic acid (quantitative).

1. temperatureis heated
2. temperatureto reflux for 2.5 hours
3. customAfter this time, the reaction vessel is fitted with a Dean-Stark trap
4. temperatureheated
5. temperatureat reflux an additional thirty minutes
6. concentrationThe reaction mixture is concentrated in vacuo