反应详情

0.6 g of sodium hydride (60%) was added to 30 ml of anhydrous N,N'-dimethylformamide. While stirring sufficiently, to the solution was added a solution of 2.13 g of trans-4-propylcyclohexanol dissolved in 10 ml of anhydrous N,N'-dimethylformamide. This mixture was continued to stirring at 50° C. for one hour and then 3.1 g of 3,4-difluorobenzyl bromide was added thereto, and the reaction was carried out at the same temperature for 3 hours with stirring. After completion of the reaction, 100 ml of water was added to the reaction mixture, the mixture was extracted with toluene, washed with a saturated NaCl aqua, dried and the solvent was removed under reduced pressure. The residue was purified by silica gel column to obtain 1.0 g of trans-4-propylcyclohexyl-3,4-difluorobenzyl ether.

1. stirringto stirring at 50° C. for one hour
2. stirringwith stirring
3. additionwas added to the reaction mixture
4. extractionthe mixture was extracted with toluene
5. washwashed with a saturated NaCl aqua
6. customdried
7. customthe solvent was removed under reduced pressure
8. customThe residue was purified by silica gel column