Methanol → HCID 54257986, compound

HRID 266786Notes

Reaction equation

HRID 266786 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[C:16]=2C=O)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(P(=[CH:43][C:44]([O:46][CH3:47])=[O:45])(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[CH3:48]O>>[CH3:48][C:18]1[CH:19]=[CH:20][C:15]([NH:14][CH:11]2[CH2:10][CH2:9][N:8]([CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[CH2:13][CH2:12]2)=[CH:16][C:17]=1[CH:21]=[CH:43][C:44]([O:46][CH3:47])=[O:45]

Participants

4

Reactant 3

HCID 887MethanolHCID 17453Acetic acid, 2-(triphenylphosphoranylidene)-, methyl esterHCID 19030840HCID 19030840, compound

Product 1

HCID 54257986HCID 54257986, compound

Procedure

To N-(1-benzyl-4-piperidinyl)-2-formyl-3-methylaniline (7.0 g) are added methanol (100 ml) and methyl (triphenylphosphoranylidene)acetate (15 g) and the mixture is refluxed for 1 hour. After cooling, the formed crystals are separated by filtration to give methyl 2-methyl-5-[(1-benzyl-4-piperidinyl)amino]cinnamate (5.6 g) as pale yellow powders, m.p. 140°-142° C.

Workup

  1. temperaturethe mixture is refluxed for 1 hour
  2. temperatureAfter cooling
  3. customthe formed crystals are separated by filtration

Sources & evidence

ORD record
ord-854cc6c9580d4c9983d5e98e42023c7f
Source dataset
uspto-grants-1997_07
Patent number
US05652247

Reaction notes

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