HCID 22875130, compound → HCID 22875156, compound

HRID 266900Notes

Reaction equation

HRID 266900 reaction equation
C(OC([N:11]1[C:50]2[C:45](=[CH:46][C:47]([F:51])=[CH:48][CH:49]=2)[C:13]2([CH2:18][CH2:17][N:16]([C:19]([C@H:21]([NH:31][C:32](=[O:44])[C:33]([NH:36][C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])([CH3:35])[CH3:34])[CH2:22][O:23][CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[O:20])[CH2:15][CH2:14]2)[CH2:12]1)=O)C1C=CC=CC=1.[H][H]>C(O)C.C(N(CC)CC)C>[F:51][C:47]1[CH:46]=[C:45]2[C:13]3([CH2:14][CH2:15][N:16]([C:19]([C@H:21]([NH:31][C:32](=[O:44])[C:33]([NH:36][C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])([CH3:35])[CH3:34])[CH2:22][O:23][CH2:24][C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=4)=[O:20])[CH2:17][CH2:18]3)[CH2:12][NH:11][C:50]2=[CH:49][CH:48]=1

Participants

5

Reactant 2

HCID 22875130HCID 22875130, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 22875156HCID 22875156, compoundYield 100.7%

Reagents, catalysts & solvents 2

HCID 8471TriethylamineCatalystHCID 702EthanolSolvent

Procedure

To a solution of 0.330 g of the intermediate obtained from Step A in 5 mL of ethanol at was added 1 drop of triethylamine and hydrogenated with hydrogen balloon for 3 h. The catalyst was filtered off through a pad of celite and washed with ethyl acetate. The filtrate was concentrated to give 0.269 g of the product as a colorless foam.

Workup

  1. filtrationThe catalyst was filtered off through a pad of celite
  2. washwashed with ethyl acetate
  3. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-40cd043345554fa9960a8ab3b3e4a0ad
Source dataset
uspto-grants-1997_07
Patent number
US05652235

Reaction notes

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