Hydrochloric Acid → HCID 21322275, compound

HRID 26713Notes

Reaction equation

HRID 26713 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:27])([C:16]#[C:17][CH2:18][CH2:19][O:20]C3CCCCO3)[CH3:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Cl>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:27])([C:16]#[C:17][CH2:18][CH2:19][OH:20])[CH3:15])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 213222332-(4'-Chloro-4-biphenylyl)-6-(tetrahydropyran-2-yloxy)-3-hexyn-2-ol

Product 1

HCID 21322275HCID 21322275, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To 38.5 g. of 2-(4'-chloro-4-biphenylyl)-6-(tetrahydropyran-2-yloxy)-3-hexyn-2-ol in 250 ml. of dioxane, is added dropwise with ice cooling, 100 ml. of 1 N HCl. The resulting mixture is stirred 12 hours more at 0°. After the usual work up, 2-(4'-chloro-4-biphenylyl)-3-hexyn-2,6-diol, m.p. 105°, is obtained.

Sources & evidence

ORD record
ord-c7073d8bbe4545fc9e2263142e00b903
Source dataset
uspto-grants-1979_04
Patent number
US04151294

Reaction notes

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