HCID 21435012, compound → HCID 178495814, compound

HRID 267522Notes

Reaction equation

HRID 267522 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([CH3:15])[N:13]=2)[C:8](=[O:16])[C:7]([C:17]([OH:19])=O)=[CH:6]1.[NH2:20][C:21]1[NH:25][N:24]=[N:23][N:22]=1>CN(C)C=O>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([CH3:15])[N:13]=2)[C:8](=[O:16])[C:7]([C:17]([NH:20][C:21]2[NH:25][N:24]=[N:23][N:22]=2)=[O:19])=[CH:6]1

Participants

4

Reactant 2

HCID 21435012HCID 21435012, compoundHCID 178509299HCID 178509299, compound

Product 1

HCID 178495814HCID 178495814, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1,4-Dihydro-1-(2-methoxyethyl)-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid (0.5 g) and N,N'-carbonyldiimidazole (0.31 g) in dimethylformamide (50 ml) were warmed at 60° for 1 hour. 5-Amino-1H-tetrazol (0.16 g) was added and the solution was stirred at 60° for 2 hours and cooled. The solid was collected and crystallised from dimethylformamide and had m.p. 245°-246° (d).

Workup

  1. temperaturecooled
  2. customThe solid was collected
  3. customcrystallised from dimethylformamide

Sources & evidence

ORD record
ord-dde86c0b3a864637adcd7b6afb0ca1ab
Source dataset
uspto-grants-1976_03
Patent number
US03943141

Reaction notes

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