Acetyl bromide → HCID 21555053, compound

HRID 267565Notes

Reaction equation

HRID 267565 reaction equation
[Br:1][CH:2]([P:6](=[O:9])([OH:8])[OH:7])[CH:3]([OH:5])[CH3:4].[Na].[C:11](Br)(=[O:13])[CH3:12]>>[Br:1][CH:2]([P:6](=[O:8])([OH:7])[OH:9])[CH:3]([O:5][C:11](=[O:13])[CH3:12])[CH3:4]

Participants

4

Reactant 3

HCID 10482Acetyl bromideHCID 5360545SodiumHCID 14285591HCID 14285591, compound

Product 1

HCID 21555053HCID 21555053, compound

Procedure

One and one-half grams of (1-bromo-2-hydroxypropyl)phosphonic acid prepared from the sodium salt obtained in Example 22 is heated with 5 ml. of acetyl bromide for one hour. The excess acetyl bromide is distilled off under reduced pressure and ice-cold water is added to the residue. The solution is stirred at room temperature and lyophilized to give (1bromo-2-acetoxypropyl)phosphonic acid.

Workup

  1. temperatureis heated with 5 ml
  2. distillationThe excess acetyl bromide is distilled off under reduced pressure and ice-cold water
  3. additionis added to the residue

Sources & evidence

ORD record
ord-764a8f27bf864da284c4e06d14273c7f
Source dataset
uspto-grants-1976_03
Patent number
US03943153

Reaction notes

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