Hydrochloric Acid → HCID 54205932, compound

HRID 267578Notes

Reaction equation

HRID 267578 reaction equation
C([NH:4][C:5]1[CH:6]=[C:7]([S:12]([O-:14])=[O:13])[CH:8]=[C:9]([Cl:11])[CH:10]=1)(=O)C.[Na+].[C:16]([O-])(=[O:18])[CH3:17].[K+].Cl[CH:22]([CH2:26]Cl)[C:23](N)=[O:24].Cl>C(O)C>[NH2:4][C:5]1[CH:6]=[C:7]([S:12]([CH:26]=[CH:22][C:23]([O:18][CH2:16][CH3:17])=[O:24])(=[O:13])=[O:14])[CH:8]=[C:9]([Cl:11])[CH:10]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 868742,3-DichloropropanamideHCID 517044Potassium AcetateHCID 23666902HCID 23666902, compound

Product 1

HCID 54205932HCID 54205932, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-carbethoxyvinyl 3-amino-5-chlorophenyl sulfone is prepared by reacting sodium 3acetamido-5-chlorobenzenesulfinate in aqueous ethanol solution, in the presence of potassium acetate, with 2,3-dichloropropionamide. The resulting 2-carboxyamidovinyl 3-acetamido-5-chlorophenyl sulfone is hydrolyzed with dilute hydrochloric acid to give 2carboxyamidovinyl 3-amino-5-chlorophenyl sulfone. The dried solid is boiled with ethanol under reflux for 2 hours in the presence of concentrated sulfuric acid. After drowning in water and neutralization 2-carbethoxyvinyl 3-amino-5-chlorophenyl sulfone is obtained.

Sources & evidence

ORD record
ord-8b2ae0612184438c897e499d5bf69ae9
Source dataset
uspto-grants-1976_03
Patent number
US03943154

Reaction notes

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