反应详情

A solution of 3α-hydroxy-11-oxo-5α-androstane-17β-carboxylic acid (521 mg.) in dry acetone (50 ml.) was refluxed with triethylamine (1.04 ml.) and n-butyl iodide (0.87 ml.) for 16 hours. The mixture was evaporated to a residue which was dissolved in chloroform, washed with water, dried (Na2SO4) and evaporated to a foam (534 mg.). A solution of the foam in ether was washed with saturated sodium bicarbonate solution and with water, dried (Na2SO4) and evaporated to give title compound (443 mg.) as a white foam, [α]D + 51°.

1. customThe mixture was evaporated to a residue which
2. dissolutionwas dissolved in chloroform
3. washwashed with water
4. dry with materialdried (Na2SO4)
5. customevaporated to a foam (534 mg.)
6. washA solution of the foam in ether was washed with saturated sodium bicarbonate solution and with water
7. dry with materialdried (Na2SO4)
8. customevaporated