huagongshe.com
HRID267624

反应详情

EQUATION

反应方程式

HRID 267624 的结构方程式

REACTANTS

反应物

2
结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：C[C@]12CCC(=O)C[C@@H]1CC[C@H]1[C@@H]3CC[C@H](C(=O)OCCCN4CCOCC4)[C@@]3(C)CC(=O)[C@@H]12
HCID22788249

未命名化合物

PRODUCTS

生成物

1
结构：C[C@]12CC[C@@H](O)C[C@@H]1CC[C@H]1[C@@H]3CC[C@H](C(=O)OCCCN4CCOCC4)[C@@]3(C)CC(=O)[C@@H]12
HCID22788262

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：Cl.Cl.O.[Cl][Ir]([Cl])([Cl])[Cl]
催化剂HCID16211483

Tetrachloroiridium--hydrogen chloride--water (1/2/1)

H4Cl6IrO

结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

A solution of 17β(3'-morpholinopropoxycarbonyl)-5α-androstan-3,11-dione (140 mg.) in isopropanol (1 ml.) was added to a "stock" solution of the chloroiridic acid reagent (7 ml.) which had been neutralised to ca. pH 6 with triethylamine immediately prior to the addition. After refluxing for 7 hr., isolation of the product afforded a gum (150 mg.) which, after purification by preparative t.l.c., gave the title compound as a white froth; 112 mg., [α]D + 51° (c, 0.6,).

WORKUP

后处理

  1. additionto the addition
  2. temperatureAfter refluxing for 7 hr
  3. custom, isolation of the product afforded a gum (150 mg.) which
  4. customafter purification by preparative t.l.c