Hydrochloric Acid → HCID 23339055, compound

HRID 26764Notes

Reaction equation

HRID 26764 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([N:11]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=2)[CH:12]2[CH2:17][CH2:16][N:15]([CH:18]([CH3:20])[CH3:19])[CH2:14][CH2:13]2)=[O:10])=[CH:4][CH:3]=1.CC(O)C.Cl>O(CC)CC.CC(=O)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([N:11]([C:21]2[CH:22]=[CH:23][C:24]([Cl:27])=[CH:25][CH:26]=2)[CH:12]2[CH2:17][CH2:16][N:15]([CH:18]([CH3:20])[CH3:19])[CH2:14][CH2:13]2)=[O:10])=[CH:6][CH:7]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3776IsopropanolHCID 20334076HCID 20334076, compound

Product 1

HCID 23339055HCID 23339055, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 3283Diethyl EtherSolvent

Procedure

5 Parts of 4-chloro-N-(4-chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]benzeneacetamide are dissolved in a mixture of 60 parts of 1,1'-oxybisethane and 16 parts of 2-propanone. The resulting solution is acidified with an excess of 2-propanol previously saturated with gaseous hydrogen chloride. The precipitated salt is filtered off and dried, yielding 7.5 parts of 4-chloro-N-(4-chlorophenyl)N-[1-(1-methylethyl)-4-piperidinyl]benzeneacetamide hydrochloride; mp. 266.6° C.

Workup

  1. filtrationThe precipitated salt is filtered off
  2. customdried

Sources & evidence

ORD record
ord-b1fb680b86bb4840ae949781fcf7cb67
Source dataset
uspto-grants-1979_04
Patent number
US04151286

Reaction notes

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