Triethylamine → N-[4-(Trifluoromethyl)phenyl]tricyclo[3.3.1.13,7]decane-1-carboxamide

HRID 267885Notes

Reaction equation

HRID 267885 reaction equation
[C:1]12([C:11](Cl)=[O:12])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[F:14][C:15]([F:24])([F:23])[C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][CH:17]=1.C(N(CC)CC)C>C(Cl)Cl.CCCCCC>[F:14][C:15]([F:23])([F:24])[C:16]1[CH:17]=[CH:18][C:19]([NH:20][C:11]([C:1]23[CH2:10][CH:5]4[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]4)[CH2:2]2)[CH2:8]3)=[O:12])=[CH:21][CH:22]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 99644-(Trifluoromethyl)anilineHCID 989151-Adamantanecarbonyl chloride

Product 1

HCID 8116872N-[4-(Trifluoromethyl)phenyl]tricyclo[3.3.1.13,7]decane-1-carboxamide

Reagents, catalysts & solvents 1

HCID 21226440Methylenechloride HexaneSolvent

Procedure

Subject 2.0 g. of adamantane carboxylic acid chloride 1.6 g. (10 mmoles) of p-trifluoromethylaniline and 5.0 ml. of triethylamine to the process of Example 11. Crystallize the residue obtained thereby from a mixture of methylene chloride-hexane to obtain the product of this Example, m.p. 189°-193°C.

Workup

  1. customCrystallize the residue
  2. customobtained
  3. customto obtain the product of this Example, m.p. 189°-193°C.

Sources & evidence

ORD record
ord-25ff76ee47d143d5806f7412c57e2710
Source dataset
uspto-grants-1976_03
Patent number
US03944675

Reaction notes

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