Phosphorus oxychloride → HCID 20528962, compound

HRID 267943Notes

Reaction equation

HRID 267943 reaction equation
NC1C(OC2C=CC=CC=2)=NC=C(OC)N=1.N([O-])=O.[Na+].O[C:22]1[C:27]([N:28]2[CH2:33][CH2:32][O:31][CH2:30][CH2:29]2)=[N:26][CH:25]=[C:24]([O:34][CH3:35])[N:23]=1.P(Cl)(Cl)([Cl:38])=O>>[Cl:38][C:22]1[C:27]([N:28]2[CH2:33][CH2:32][O:31][CH2:30][CH2:29]2)=[N:26][CH:25]=[C:24]([O:34][CH3:35])[N:23]=1

Participants

5

Reactant 4

HCID 24813Phosphorus oxychlorideHCID 20528937HCID 20528937, compoundHCID 23668193Sodium NitriteHCID 178493780HCID 178493780, compound

Product 1

HCID 20528962HCID 20528962, compound

Procedure

The 2-amino substituent of Step A product when treated with sodium nitrite as described in Step E of Preparation 81 is converted to the 2-hydroxy group. Treatment of the 2-hydroxy-3-morpholino-6-methoxypyrazine with phosphorus oxychloride by Preparation 13, Step B method, gives 2-chloro-3-morpholino-6-methoxypyrazine.

Workup

  1. customas described in Step E of Preparation 81

Sources & evidence

ORD record
ord-15e1aa1efc844950a563ade16aa65608
Source dataset
uspto-grants-1976_03
Patent number
US03946009

Reaction notes

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