Hydrochloric Acid → HCID 21553006, compound

HRID 267970Notes

Reaction equation

HRID 267970 reaction equation
[CH:1]1[C:6]2[N:7]=[C:8]3[CH:15]=[CH:14][CH:13]=[CH:12][N:9]3[CH2:10][S:11][C:5]=2[CH:4]=[CH:3][CH:2]=1.[ClH:16]>CC(O)C.CCOCC>[ClH:16].[CH:1]1[C:6]2[N:7]=[C:8]3[CH:15]=[CH:14][CH:13]=[CH:12][N:9]3[CH2:10][S:11][C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 12235834HCID 12235834, compound

Product 1

HCID 21553006HCID 21553006, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 3776IsopropanolSolvent

Procedure

To a solution of 1.0 g of 6H-pyrido[1,2-c][1,3,5]-benzothiadiazepine in 20 ml of anhydrous 2-propanol is added about 5.0 ml of 4.2 N 2-propanolic hydrogen chloride. The clear solution that is formed is diluted with anhydrous ether until a turbidity persists and is then cooled to give the pale yellow crystalline product. Recrystallization from acetonitrile gives about 1.0 g of the named product, mp about 258°-260°.

Workup

  1. customThe clear solution that is formed
  2. temperatureis then cooled
  3. customto give the pale yellow crystalline product
  4. customRecrystallization from acetonitrile

Sources & evidence

ORD record
ord-e05809dab153426d91495342a7424e34
Source dataset
uspto-grants-1976_03
Patent number
US03946025

Reaction notes

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